High WEE1 Expression is Independently Linked to Poor Survival in Multiple Myeloma

Background

Thanks for your interest in this work! This project was inspired by our orignal work taking an unsupervised network-based approach to a large multiple myeloma (MM) data. This paper, Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival - Blood Cancer Journal, described a novel eight gene signature associated with high-risk multiple myeloma: BUB1, MCM6, NOSTRIN, PAM, RNF115, SNCAIP, SPRR2A, & WEE1.

WEE1 is a strong prognostic marker of high-risk MM

Of all 8 genes, WEE1 was the most prognostic. So we decided to do a deeper dive and fully explore the prognostic value of WEE1 in newly diagnosed multiple myeloma (NDMM) and how it alters gene expression. These results are shared as a poster for the 2024 International Myeloma Society meeting and can be viewed here.

This work is available as a preprint on biorxiv here.

If you also work on WEE1 or other cell cycle genes, I’d love to hear from you! Please email me at simhala [at] mskcc [dot] org.